PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Benzyl (5-oxopentyl)carbamate
0 ImagesCat. No.: HY-W639342CAS No.: 188530-60-1
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tert-Butyldimethyl(2-(prop-2-yn-1-yloxy)ethoxy)silane
0 ImagesCat. No.: HY-W570678CAS No.: 339531-56-5
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(4-(((1-(Tert-butoxycarbonyl)piperidin-4-yl)oxy)methyl)phenyl)boronic acid
0 ImagesCat. No.: HY-W118240CAS No.: 1224449-13-1
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Ethyl 4-aminobutanoate
0 ImagesCat. No.: HY-W556272CAS No.: 5959-36-4
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(4-(3-Bromopropoxy)phenyl)boronic acid
0 ImagesCat. No.: HY-W117408CAS No.: 957034-33-2
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COOEt-spiro[3.3]heptane-CHO
![COOEt-spiro[3.3]heptane-CHO](https://file.medchemexpress.com/product_pic/hy-159539.gif "Click to View COOEt-spiro[3.3]heptane-CHO Product Detail")
0 ImagesCat. No.: HY-159539CAS No.: 2226571-47-5
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Thiol-PEG5-acid
0 ImagesCat. No.: HY-133290CAS No.: 1449390-67-3Synonyms: HS-PEG5-CH2CH2COOH
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1,11-Diaminoundecane
0 ImagesCat. No.: HY-W110322CAS No.: 822-08-2
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tert-Butyl 4-(4-bromophenoxy)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W090887CAS No.: 308386-38-1
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BG-PEG4-DBCO
0 ImagesCat. No.: HY-W1130311
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tert-Butyl 4-chlorobutanoate
0 ImagesCat. No.: HY-W069230CAS No.: 3153-32-0
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bis (Boc-Azetidine)
0 ImagesCat. No.: HY-W837047CAS No.: 2757731-43-2
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2-(2-Bromoethoxy)ethan-1-amine
0 ImagesCat. No.: HY-W792642CAS No.: 471910-67-5
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Docosanedioic acid (Standard)
0 ImagesCat. No.: HY-W034918RCAS No.: 505-56-6Docosanedioic acid (Standard) is the analytical standard of Docosanedioic acid (HY-W034918). This product is intended for research and analytical applications. Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
